Opelika is a city in and the county seat of Lee County in the east central part of the State of Alabama. It is a principal city of the Auburn-Opelika Metropolitan Area. According to the 2013 Census Estimate, the population of Opelika was 28,635. The Auburn-Opelika, AL MSA with a population of 150,933 which, along with the Columbus, Georgia metropolitan area and Macon County, Alabama, comprises the greater Greater Columbus, Georgia, a region home to 501,649 residents.